Monomers, polymers, copolymers, resins, and coated silicas containing benzylamine residues planned as artificial substrates of benzylamine oxidase

Author(s):  
V. Bertini ◽  
M. Pocci ◽  
N. Picci ◽  
A. Demunno ◽  
F. Lucchesini ◽  
...  
1999 ◽  
Vol 5 (S2) ◽  
pp. 398-399
Author(s):  
P. Sims ◽  
B. Todd ◽  
S. Eppell ◽  
T. Li ◽  
K. Park ◽  
...  

Adherent cells generally construct the immediate substrate upon which they reside. This may occur via synthesis and secretion of new materials and/or by rearrangement and modification of existing substrate. The response of adherent cell types to an existing substrate can be influenced by a number of factors which include both the chemical and physical nature of the substrate. Cell adhesion, proliferation, differentiation and death can all be substrate dependent. Much effort has been directed toward chemical modification of substrates to regulate one or more of the parameters noted above. A significant, but somewhat smaller, degree of attention has been paid to the effects of the topography and microtopography on the cell response to substrate materials. Studies to date strongly suggest the topography is a significant factor in cell-substrate interactions. As noted above, it is most probable that both the chemistry and the structure of a substrate simultaneously influence the cellular response. However we wished to determine, particularly for artificial substrates, the role which microtopography can play in cell-substrate interactions.


2016 ◽  
Vol 28 (0) ◽  
Author(s):  
Lívia Borges dos Santos ◽  
Cyntia Goulart Côrrea Bruno ◽  
Jean Carlos Santos

Abstract: Aim To analyze the efficiency of organic and inorganic substrates in samples of benthic macroinvertebrates of riparian forests from the Cerrado. Specific objectives (i) characterize the ecological succession and taxonomic richness of benthic macroinvertebrates in stream affluent of a riparian forest; (ii) analyze the influence of seasonality on the colonization of macroinvertebrates; and (iii) determine the effect of the types of artificial substrates on the richness, composition and abundance of the benthic community. Methods Sampling was carried out in the rainy and dry seasons, and we installed in the watercourse two types of substrates: organic (leaf packs) and inorganic (bricks), organized in pairs. Six samples per season were done to verify colonization, succession, richness and abundance of benthic community. The substrates were carefully sorted and the organisms were identified to the lowest possible taxonomic level. Results The ecological succession was clearly observed, with the initial occurrence of Chironomidae and Baetidae (considered early colonizers), and a late occurrence of organisms such as Helotrephidae and Trichoptera (considered late colonizers). No significant difference was found in the richness and abundance among the studied seasons (rainy and dry), but the organic substrate was significantly higher than the inorganic substrate for these parameters. Conclusion Organic artificial substrates are more efficient in characterizing the community of benthic macroinvertebrates in the study area, because they are more similar to the conditions of the substrate found naturally in the environment.


Hydrobiologia ◽  
1993 ◽  
Vol 260-261 (1) ◽  
pp. 415-420 ◽  
Author(s):  
Flavio A. S. Berchez ◽  
Ricardo T. L. Pereira ◽  
Neide F. Kamiya

2003 ◽  
Vol 197 (9) ◽  
pp. 1173-1181 ◽  
Author(s):  
Il-mi Okazaki ◽  
Hiroshi Hiai ◽  
Naoki Kakazu ◽  
Shuichi Yamada ◽  
Masamichi Muramatsu ◽  
...  

Genome stability is regulated by the balance between efficiencies of the repair machinery and genetic alterations such as mutations and chromosomal rearrangements. It has been postulated that deregulation of class switch recombination (CSR) and somatic hypermutation (SHM), which modify the immunoglobulin (Ig) genes in activated B cells, may be responsible for aberrant chromosomal translocations and mutations of non-Ig genes that lead to lymphocyte malignancy. However, the molecular basis for these genetic instabilities is not clearly understood. Activation-induced cytidine deaminase (AID) is shown to be essential and sufficient to induce both CSR and SHM in artificial substrates in fibroblasts as well as B cells. Here we show that constitutive and ubiquitous expression of AID in transgenic mice caused both T cell lymphomas and dysgenetic lesions of epithelium of respiratory bronchioles (micro-adenomas) in all individual mice. Point mutations, but not translocations, were massively introduced in expressed T cell receptor (TCR) and c-myc genes in T lymphoma cells. The results indicate that AID can mutate non-Ig genes including oncogenes, implying that aberrant AID expression could be a cause of human malignancy.


2018 ◽  
Author(s):  
Pedro Range ◽  
Rodrigo Riera ◽  
Naeem Abdulaziz Aziz ◽  
Mohammed Mustafa Al Dibis ◽  
Jessica Bouwmeester ◽  
...  

1991 ◽  
Vol 117 (4) ◽  
pp. 394-407 ◽  
Author(s):  
Peter S. Burgoon ◽  
Thomas A. DeBusk ◽  
K. R. Reddy ◽  
Ben Koopman

1989 ◽  
Vol 46 (6) ◽  
pp. 1047-1061 ◽  
Author(s):  
Robert J. Sebastien ◽  
Reinhart A. Brust ◽  
David M. Rosenberg

The insecticide methoxychlor was applied at 300 μg∙L−1 for 15 min to a riffie on the Souris River, located about 18 km downstream from Souris, Manitoba. Physical, chemical, and biological variables were measured and aquatic insect community structure was monitored using drift, emergence trap, and artificial substrate samplers. All taxa monitored, irrespective of functional feeding group, drifted catastrophically for 4–24 h immediately following methoxychlor addition. Different species demonstrated varying abilities to recoionize artificial substrates following treatment. Species having a high propensity to drift naturally, recolonized most rapidly. Taxa that required the longest period to recoionize following methoxychlor treatment were generally univoltine, had a low propensity to drift, and a limited ability to disperse as adults. Impact of methoxychlor was influenced by the prevalent life-cycle stage of some species at the time of treatment. Catostomus commersoni fry and juvenile Orconectes virilis were more sensitive to methoxychlor than previous research on mature individuals has indicated. Invertebrate drift appeared to be more sensitive to pesticide treatment than benthic invertebrates on artificial substrates. Species richness and total numbers of drift were significantly reduced for at least 33 d following treatment, whereas richness and numbers on artificial substrates were significantly lower for only 4 and 8 d, respectively.


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